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Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake

Genes and Development, ISSN: 0890-9369, Vol: 24, Issue: 14, Page: 1491-1495
2010
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Article Description

Inactivation of the yeast nonsense-mediated mRNA decay (NMD) pathway stabilizes nonsense mRNAs and promotes readthrough of premature translation termination codons. Although the latter phenotype is thought to reflect a direct role of NMD factors in translation termination, its mechanism is unknown. Here we show that the reduced termination efficiency of NMD-deficient cells is attributable to increased expression of the magnesium transporter Alr1p and the resulting effects of elevated Mg levels on termination fidelity. Alr1p levels increase because an upstream ORF in ALR1 mRNA targets the transcript for NMD. Our results demonstrate that NMD, at least in yeast, controls Mg homeostasis and, consequently, translational fidelity. © 2010 by Cold Spring Harbor Laboratory Press.

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