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Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

Learning and Memory, ISSN: 1072-0502, Vol: 16, Issue: 5, Page: 332-337
2009
  • 121
    Citations
  • 0
    Usage
  • 112
    Captures
  • 0
    Mentions
  • 20
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    121
  • Captures
    112
  • Social Media
    20
    • Shares, Likes & Comments
      20
      • Facebook
        20

Article Description

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-α agonist WY14643, and these enhancements were blocked by the PPAR-α antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-α, either directly by administering a PPAR-α agonist or indirectly by administering a FAAH inhibitor.

Bibliographic Details

Mazzola, Carmen; Medalie, Julie; Scherma, Maria; Panlilio, Leigh V; Solinas, Marcello; Tanda, Gianluigi; Drago, Filippo; Cadet, Jean Lud; Goldberg, Steven R; Yasar, Sevil

Cold Spring Harbor Laboratory

Psychology; Neuroscience

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