Biomolecular implementation of a quasi sliding mode feedback controller based on DNA strand displacement reactions
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, ISSN: 1557-170X, Vol: 2015-November, Page: 949-952
2015
- 12Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef4
- Captures10
- Readers10
- 10
Conference Paper Description
A fundamental aim of synthetic biology is to achieve the capability to design and implement robust embedded biomolecular feedback control circuits. An approach to realize this objective is to use abstract chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks. Here, we employ this approach to facilitate the implementation of a class of nonlinear feedback controllers based on sliding mode control theory. We show how a set of two-step irreversible reactions with ultrasensitive response dynamics can provide a biomolecular implementation of a nonlinear quasi sliding mode (QSM) controller. We implement our controller in closed-loop with a prototype of a biological pathway and demonstrate that the nonlinear QSM controller outperforms a traditional linear controller by facilitating faster tracking response dynamics without introducing overshoots in the transient response.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84953218925&origin=inward; http://dx.doi.org/10.1109/embc.2015.7318520; http://www.ncbi.nlm.nih.gov/pubmed/26736420; http://ieeexplore.ieee.org/document/7318520/; http://xplorestaging.ieee.org/ielx7/7302811/7318236/07318520.pdf?arnumber=7318520; https://ieeexplore.ieee.org/document/7318520/
Institute of Electrical and Electronics Engineers (IEEE)
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