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Atypical Cells in Lymphomatoid Papulosis Express the Hodgkin Cell-Associated Antigen Ki-1

Journal of Investigative Dermatology, ISSN: 0022-202X, Vol: 86, Issue: 4, Page: 350-354
1986
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Article Description

Lymphomatoid papulosis (LyP) is characterized by the presence of large multinucleated cells resembling Reed- Sternberg (RS) cells. Evidence of antigenic similarity between these two cell types has been sought by immunohistologic labeling of 10 biopsies from cases of LyP with monoclonal antibodies against Ki-I and other RS and Hodgkin (H) cell-associated antigens. In all cases studied, a proportion of the large atypical cells expressed the Ki-1 antigen. On the contrary, in 20 biopsies of benign skin lesions or cutaneous T-cell lymphomas, Ki-1-positive cells were absent or only occasionally present. Furthermore the large atypical cells of LyP also expressed antigens (e.g., T3, T4, HLA-DR, IL-2 receptors) which we have previously demonstrated on RS cells in the majority of cases of Hodgkin's disease (HD). These findings, in conjunction with the observation that Ki-1 antigen expression can be induced on peripheral blood lymphocytes following exposure to phytohemagglutinin or HTLV 1, provide evidence that the Ki-1 positive cells in LyP represent activated T cells as RS cells do in many cases of HD.

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