Atypical Cells in Lymphomatoid Papulosis Express the Hodgkin Cell-Associated Antigen Ki-1
Journal of Investigative Dermatology, ISSN: 0022-202X, Vol: 86, Issue: 4, Page: 350-354
1986
- 73Citations
- 6Captures
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Metrics Details
- Citations73
- Citation Indexes73
- CrossRef73
- 62
- Captures6
- Readers6
Article Description
Lymphomatoid papulosis (LyP) is characterized by the presence of large multinucleated cells resembling Reed- Sternberg (RS) cells. Evidence of antigenic similarity between these two cell types has been sought by immunohistologic labeling of 10 biopsies from cases of LyP with monoclonal antibodies against Ki-I and other RS and Hodgkin (H) cell-associated antigens. In all cases studied, a proportion of the large atypical cells expressed the Ki-1 antigen. On the contrary, in 20 biopsies of benign skin lesions or cutaneous T-cell lymphomas, Ki-1-positive cells were absent or only occasionally present. Furthermore the large atypical cells of LyP also expressed antigens (e.g., T3, T4, HLA-DR, IL-2 receptors) which we have previously demonstrated on RS cells in the majority of cases of Hodgkin's disease (HD). These findings, in conjunction with the observation that Ki-1 antigen expression can be induced on peripheral blood lymphocytes following exposure to phytohemagglutinin or HTLV 1, provide evidence that the Ki-1 positive cells in LyP represent activated T cells as RS cells do in many cases of HD.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022202X86904707; http://dx.doi.org/10.1111/1523-1747.ep12285562; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0022501943&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2427610; https://linkinghub.elsevier.com/retrieve/pii/S0022202X86904707; https://dx.doi.org/10.1111/1523-1747.ep12285562
Elsevier BV
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