Predominance of activated, clonally expanded T helper type 17 cells within the CD4 T cell population in psoriatic lesions
Clinical and Experimental Immunology, ISSN: 0009-9104, Vol: 173, Issue: 1, Page: 38-46
2013
- 22Citations
- 32Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef17
- Captures32
- Readers32
- 32
Article Description
Recent evidence points to the T helper type 17 (Th17) subset as key in the pathogenesis of psoriasis, but cells of this type in lesions remain to be fully characterized. Here we isolated, enumerated, functionally tested and clonotyped the CD4 Th cell population ex vivo from lesional biopsies and paired peripheral blood samples from psoriasis patients. Th17 cells were over-represented dramatically in lesions from all patients, representing 49-93% of CD4 Th cells compared with 3-18% in blood. Most lesional Th17 cells produced interleukin (IL)-17Aex vivo without further stimulation and expressed the CD45RO phenotype characteristic of activated or memory cells. There was no increase in 'natural' [CD25forkhead box protein 3 (FoxP3)] regulatory T cells in lesions versus peripheral blood, but there was enrichment of 'induced' IL-10 regulatory T cell numbers in biopsies from some patients. The lesional Th17 cells exhibited a bias in T cell receptor Vβ chain usage, suggestive of specific expansion by antigen. The therapeutic challenge is to overcome the dominance of overwhelming numbers of such antigen-specific Th17 cells in psoriatic lesions. © 2013 British Society for Immunology.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84878795813&origin=inward; http://dx.doi.org/10.1111/cei.12086; http://www.ncbi.nlm.nih.gov/pubmed/23607572; https://academic.oup.com/cei/article/173/1/38/6420990; https://dx.doi.org/10.1111/cei.12086; https://academic.oup.com/cei/article-abstract/173/1/38/6420990?redirectedFrom=fulltext
Oxford University Press (OUP)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know