Immunoregulation therapy changes the frequency of interleukin (IL)-22CD4 T cells in systemic lupus erythematosus patients
Clinical and Experimental Immunology, ISSN: 0009-9104, Vol: 177, Issue: 1, Page: 212-218
2014
- 22Citations
- 38Captures
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef14
- Captures38
- Readers38
- 38
Article Description
T cell and T cell-related cytokine abnormalities are involved in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study showed that the interleukin (IL)-22CD4T cells and IL-22 play an important role in the pathogenesis of SLE. In this study, we aimed to investigate the effects of glucocorticoids (GCs) and immunodepressant agents on IL-22 and IL-22-producing T cell subsets in SLE patients. The frequencies of peripheral blood T helper type 22 (Th22), IL-22Th17, IL-22Th1 and Th17 cells and the concentrations of serum IL-22, IL-17 and interferon (IFN)-γ in SLE patients receiving 4 weeks of treatment with cyclophosphamide (CYC), methylprednisolone and hydroxychloroquine (HCQ) were characterized by flow cytometry analysis and enzyme-linked immunosorbent assay (ELISA). The frequencies of Th22, IL-22 Th17 and Th17 cells and the concentrations of IL-22 and IL-17 were reduced in response to the drugs methylprednisolone, cyclophosphamide and hydroxychloroquine for 4 weeks in the majority of SLE patients. However, the percentage of Th1 cells showed no change. No differences in the levels of IL-22 and IL-22CD4 T cells were found between non-responders and health controls either before or after therapy. IL-22 levels were correlated positively with Th22 cells in SLE patients after treatment. These results suggest that elevated IL-22 is correlated with IL-22CD4T cells, especially Th22 cells, and may have a co-operative or synergetic function in the immunopathogenesis of SLE. GC, CYC and HCQ treatment may regulate the production of IL-22, possibly by correcting the IL-22CD4T cells polarizations in SLE, thus providing new insights into the mechanism of GC, CYC and HCQ in the treatment of SLE. © 2014 British Society for Immunology.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904242098&origin=inward; http://dx.doi.org/10.1111/cei.12330; http://www.ncbi.nlm.nih.gov/pubmed/24635166; https://academic.oup.com/cei/article/177/1/212/6421372; https://dx.doi.org/10.1111/cei.12330; https://academic.oup.com/cei/article-abstract/177/1/212/6421372?redirectedFrom=fulltext
Oxford University Press (OUP)
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