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Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2×2 factorial randomized trial

Diabetes, Obesity and Metabolism, ISSN: 1463-1326, Vol: 16, Issue: 10, Page: 1032-1035
2014
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Article Description

The benefits of exercise and behavioural recommendations in gestational diabetes mellitus (GDM) are controversial. In a randomized trial with a 2×2 factorial design, we examined the effect of exercise and behavioural recommendations on metabolic variables, and maternal/neonatal outcomes in 200 GDM patients. All women were given the same diet: group D received dietary recommendations only; group E was advised to briskly walk 20-min/day; group B received behavioural dietary recommendations; group BE was prescribed the same as B+E. Dietary habits improved in all groups. In a multivariable regression model, fasting glucose did not change. Exercise, but not behavioural recommendations, was associated with the reduction of postprandial glucose (p<0001), glycated haemoglobin (HbA1c; p<0.001), triglycerides (p=0.02) and C-reactive protein (CRP; p<0.001) and reduced any maternal/neonatal complications (OR = 0.50; 95%CI=0.28-0.89;p=0.02). In GDM patients a simple exercise programme reduced maternal postprandial glucose, HbA1c, CRP, triglycerides and any maternal/neonatal complications, but not fasting glucose values.

Bibliographic Details

Simona Bo; S. Canil; R. Gambino; G. Grassi; E. Ghigo; M. Cassader; R. Rosato; G. Ciccone; C. B. Poala; G. Menato; F. Leone; A. Valla

Wiley

Medicine; Biochemistry, Genetics and Molecular Biology

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