PlumX Metrics
Embed PlumX Metrics

Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: A multicenter randomized controlled trial

European Journal of Neurology, ISSN: 1351-5101, Vol: 20, Issue: 8, Page: 1161-1169
2013
  • 60
    Citations
  • 0
    Usage
  • 49
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Background and purpose: We investigated the effect of celecoxib, a selective inhibitor of cyclo-oxygenase 2, in patients with intracerebral hemorrhage (ICH). Methods: We conducted a multicenter, randomized, controlled, and open with blinded end-point trial of 44 Korean patients 18years or older with ICH within 24h of onset. The intervention group (n=20) received celecoxib (400mg twice a day) for 14days. The control group (n=24) received the standard medical treatment for ICH. The primary end-point was the number of patients with a change in the volume of perihematomal edema (PHE) from the 1st to the 7th±1day (cut-off value, 20%). Results: The time from onset to computed tomography scan slightly differed between groups (177±160min for control vs. 297±305min for the celecoxib group; P=0.10). In the primary end-point analysis using cut-off values, there was a significant shift to reduced expansion of PHE in the celecoxib group (P=0.005). With respect to the secondary end-points, there was also a significant shift to reduced expansion of ICH in the celecoxib group (P=0.046). In addition, the expansion rate of PHE at follow-up tended to be higher in the control group than in the celecoxib group (90.6±91.7% vs. 44.4±64.9%; P=0.058). Conclusions: In our small, pilot trial, administration of celecoxib in the acute stage of ICH was associated with a smaller expansion of PHE than that observed in controls. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

Bibliographic Details

S. H. Lee; C. K. Kim; E. S. Park; J. W. Chung; K. H. Jung; J. K. Roh; H. K. Park; W. S. Ryu; J. S. Lee; H. J. Bae; M. K. Han; Y. S. Lee; H. M. Kwon

Wiley

Neuroscience; Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know