Significance of membrane type 1 matrix metalloproteinase expression in breast cancer
Japanese Journal of Cancer Research, ISSN: 0910-5050, Vol: 90, Issue: 5, Page: 516-522
1999
- 30Citations
- 1Captures
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Metrics Details
- Citations30
- Citation Indexes30
- 30
- CrossRef25
- Captures1
- Readers1
Article Description
Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis and invasion through the degradation of extracellular matrix (ECM). MT1-MMP (membrane type 1 matrix metalloproteinase), a membrane-type MMP, is responsible for the activation of MMP2. In this study the significance of MT1-MMP expression in human breast tumors was investigated by immunocytochemical assay, and its correlation with clinicobiological features was analyzed. MT1-MMP expression was detected in tumor cells and/or stromal cells, and there was a strong correlation between the expressions of MT1-MMP in the two cell types. Out of 183 primary tumors, 103 (56.2%) showed positive staining of MT1-MMP in tumor cells. MT1-MMP expression showed no significant correlation with any of the clinicobiological parameters examined, including hormone receptor status and angiogenesis. In postoperative survival analysis, MT1-MMP expression itself was not a significant prognostic factor. However, in the particular subgroup with the accumulation of thymidine phosphorylase (TP)-positive stromal cells, which have been activated by various stimuli, such as cytokines and hypoxia, MT1-MMP expression had a significant prognostic value. These data suggested that MT1-MMP might function cooperatively with tumor-associated stromal cells for the progression of breast cancer.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033002459&origin=inward; http://dx.doi.org/10.1111/j.1349-7006.1999.tb00778.x; http://www.ncbi.nlm.nih.gov/pubmed/10391091; https://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.1999.tb00778.x; https://dx.doi.org/10.1111/j.1349-7006.1999.tb00778.x
Wiley
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