Topical glucocorticoids and suppression of contact sensitivity. A mouse bioassay of anti‐inflammatory effects
British Journal of Dermatology, ISSN: 1365-2133, Vol: 112, Issue: 5, Page: 539-545
1985
- 5Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
A mouse model for assessment of the anti‐inflammatory effect of topical glucocorticoids is described. Mice, sensitized to picryl chloride, had both ears painted with the sensitizer followed 2 hours later by the application of the topical steroid to one ear and the corresponding vehicle to the other. The contact sensitivity reaction, measured by swelling of the ear, was recorded 24 hours later. Dilutions of the steroid formulations inhibited the ear swelling in a manner related to dose‐response. Suppression of the contact sensitivity reaction of the vehicle‐treated ear as well was regarded as a systemic effect of the glucocorticoid. There seems to be a good correlation between the efficacy of the topical steroids assessed in this mouse model and the vasoconstrictor test on intact human skin. Copyright © 1985, Wiley Blackwell. All rights reserved
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021798386&origin=inward; http://dx.doi.org/10.1111/j.1365-2133.1985.tb15261.x; http://www.ncbi.nlm.nih.gov/pubmed/4005154; https://academic.oup.com/bjd/article/112/5/539/6689645; https://dx.doi.org/10.1111/j.1365-2133.1985.tb15261.x; https://academic.oup.com/bjd/article-abstract/112/5/539/6689645?redirectedFrom=fulltext
Oxford University Press (OUP)
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