VLA protein expression on epidermal cells (keratinocytes, Langerhans cells, melanocytes): A light and electron microscopic immunohistochemical study
British Journal of Dermatology, ISSN: 0007-0963, Vol: 124, Issue: 2, Page: 135-145
1991
- 46Citations
- 6Captures
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Metrics Details
- Citations46
- Citation Indexes46
- 46
- CrossRef40
- Captures6
- Readers6
Article Description
The very late antigens, or VLA proteins, are a family of cell surface heterodimers (αβ) that mediate cell adhesion to specific components of the extracellular matrix (collagens, fibronectin, laminin). In normal human epidermis, the common VLA β subunit is expressed on basal keratinocytes (BK), Langerhans cells (LC) and melanocytes. By means of light and electron microscopic immunostaining procedures, we have investigated the distribution of VLA α subunits on normal human adult and foetal epidermal cells. α antigen expression was not observed on any epidermal cell type. Both during foetal development and in adult epidermis, α and α were strongly expressed on the cell membrane of BK, while α was mainly expressed at their dermal pole. These different patterns of distribution suggest that the α subunit may mediate BK anchorage to the basement membrane zone, while the α and α subunits may also be involved in intercellular adhesion. Moreover, with immunoelectron microscopy, LC were seen to be weakly α and α positive and melanocytes were α and α positive. Thus, VLA proteins are expressed by epidermal cells in a cell-type-specific pattern that could be related to particular functional roles of these proteins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026011506&origin=inward; http://dx.doi.org/10.1111/j.1365-2133.1991.tb00422.x; http://www.ncbi.nlm.nih.gov/pubmed/2003995; https://academic.oup.com/bjd/article/124/2/135/6685621; https://dx.doi.org/10.1111/j.1365-2133.1991.tb00422.x; https://academic.oup.com/bjd/article-abstract/124/2/135/6685621?redirectedFrom=fulltext
Oxford University Press (OUP)
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