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Failure of omalizumab in cholinergic urticaria: Clinical dermatology • Concise report

Clinical and Experimental Dermatology, ISSN: 0307-6938, Vol: 35, Issue: 4, Page: e127-9
2010
  • 47
    Citations
  • 0
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  • 25
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  • 2
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  • 0
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Efficacy Study of Omalizumab in Cholinergic Urticaria; CUN-OMAL-UCOL

STUDY INFORMATION OFFICIAL TITLE: Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial

Article Description

Cholinergic urticaria is one of the more common physical urticarias. Although it is often fairly mild, severe treatment-resistant disease may occur, with significant associated disability. Omalizumab, a monoclonal IgG anti-IgE antibody licensed for use in severe asthma, has recently been used successfully in several types of urticaria, including in one case of cholinergic urticaria. This paper reports a patient with severe cholinergic urticaria, unresponsive to antihistamines and multiple other treatments, whose disease was also unresponsive to omalizumab. © 2009 British Association of Dermatologists.

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