Human NK cells require caspases for activation-induced proliferation and cytokine release but not for cytotoxicity
Scandinavian Journal of Immunology, ISSN: 0300-9475, Vol: 72, Issue: 5, Page: 388-395
2010
- 7Citations
- 14Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
- Captures14
- Readers14
- 14
Article Description
Natural killer (NK) cells are innate immune cells involved in antiviral defence and tumour surveillance. To fulfil these tasks, NK cells make use of two major effector functions, cytokine and chemokine release and cytotoxicity. In addition, NK cells proliferate in response to cytokines such as IL-2. NK cells possess a large array of activating and inhibitory receptors and their activation demands a complex crosstalk between those receptors. The signalling pathways leading to NK-cell activation are a field of intensive research. The first clue for signal specificity was provided by studies showing that a pathway leading to NF-κB activation selectively induces cytokine release, but is dispensable for cytotoxicity. Here, we demonstrate that in human NK cells caspase activity is required for the upregulation of select activation markers and IFN- γ and TNF production, but not for cytotoxicity. Interestingly, caspases have previously been linked in T cells to the same mechanism of NF-ΚB induction that is active in NK cells. Moreover, we provide evidence that caspases are involved in IL-2-induced proliferation. Thus, our data provide the basis for a novel approach using caspase inhibitors to generate cytotoxic NK cells, while simultaneously suppressing cytokine release. © 2010 The Authors. Scandinavian Journal of Immunology © 2010 Blackwell Publishing Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958106577&origin=inward; http://dx.doi.org/10.1111/j.1365-3083.2010.02449.x; http://www.ncbi.nlm.nih.gov/pubmed/21039733; https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02449.x; https://dx.doi.org/10.1111/j.1365-3083.2010.02449.x
Wiley
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