An Antagonistic Mutant of Interleukin‐4 Fails to Recruit γc into the Receptor Complex: Characterization by Specific Crosslinking
European Journal of Biochemistry, ISSN: 1432-1033, Vol: 228, Issue: 2, Page: 305-310
1995
- 25Citations
- 2Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The receptor for interleukin‐4 (IL‐4) appears to be a heterodimer of the IL‐4‐binding protein IL‐Rα and the γc chain. Mutations of IL‐4 have previously identified a region of IL‐4 essential for signaling, which was suggested to bind γc. Here it is shown by crosslinking of radiolabeled ligand and precipitation with specific antibodies that mutations in the IL‐4 signaling site prevent association of γc, but not binding to IL‐4Rα. This demonstrates that an intact signaling site of IL‐4 is required to recruit γc into the receptor complex, while specific mutants are antagonists because they fail to achieve this. Copyright © 1995, Wiley Blackwell. All rights reserved
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know