ACTIVATION OF Na+/H+ EXCHANGE IS UNNECESSARY IN THE INDUCTION OF c‐fos mRNA IN SERUM‐STIMULATED VASCULAR SMOOTH MUSCLE CELLS
Clinical and Experimental Pharmacology and Physiology, ISSN: 1440-1681, Vol: 18, Issue: 8, Page: 543-549
1991
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Article Description
1. The effects of extracellular Na+ concentration ([Na+]) on serum‐stimulated c‐fos mRNA induction in vascular smooth muscle cells (VSMC) were studied to examine whether the activation of Na+/H+ exchange and the following intracellular alkalinization are necessary in the induction of c‐fos in VSMC. 2. When monitored with 2′, 7′‐bis (carboxylethyl)‐5(6)‐carboxyfluorescein, the reduction in [Na+] in HCO‐free buffer caused a dose‐dependent inhibition of Na+‐dependent intracellular pH recovery in acid‐loaded VSMC. In addition, serum‐stimulated intracellular alkalinization in VSMC was completely blocked by the removal of extracellular Na+. 3. By contrast, c‐fos induction, quantified by slit blot hybridization of c‐fos mRNA, was not fully inhibited by the reduction of [Na+]. Furthermore, amiloride and ethylisopropyl‐amiloride, inhibitors of Na+/H+ exchange, only partially blocked c‐fos induction by serum. 4. We concluded from the observation above, that the intracellular alkalinization caused by the activation of Na+/H+ exchange was unnecessary in serum‐stimulated induction of c‐fos mRNA in VSMC. Copyright © 1991, Wiley Blackwell. All rights reserved
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025862252&origin=inward; http://dx.doi.org/10.1111/j.1440-1681.1991.tb01489.x; http://www.ncbi.nlm.nih.gov/pubmed/1914252; https://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.1991.tb01489.x; https://dx.doi.org/10.1111/j.1440-1681.1991.tb01489.x
Wiley
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