COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HAEMOGLOBIN
British Journal of Pharmacology, ISSN: 1476-5381, Vol: 57, Issue: 2, Page: 201-209
1976
- 114Citations
- 65Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations114
- Citation Indexes114
- 114
- CrossRef93
- Captures65
- Readers65
- 63
Article Description
The three‐dimensional coordinates of the atoms in human haemoglobin are known, and there is a specific site in the deoxygenated form of the protein at which 2,3‐diphosphoglycerate (DPG) interacts. Molecular models of this site have been constructed and used to design compounds which should bind to the deoxy conformation and stabilize it. These compounds should thereby promote oxygen liberation, as does DPG. The compounds so designed were found to promote oxygen liberation. Their relative potencies, as assessed by sigmoidal dose‐response curves, are in the predicted sequence. 1976 British Pharmacological Society
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0017184784&origin=inward; http://dx.doi.org/10.1111/j.1476-5381.1976.tb07468.x; http://www.ncbi.nlm.nih.gov/pubmed/938794; https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1976.tb07468.x; https://dx.doi.org/10.1111/j.1476-5381.1976.tb07468.x; https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.1976.tb07468.x
Wiley
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