Tolerance to acute ethanol inhibition of peptide hormone release in the isolated neurohypophysis
Alcoholism: Clinical and Experimental Research, ISSN: 0145-6008, Vol: 24, Issue: 7, Page: 1077-1083
2000
- 21Citations
- 12Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Background: Acute ethanol (EtOH) exposure reduces the evoked release of vasopressin (AVP) and oxytocin (OT) from excised neurohypophyses and from dissociated neurohypophysial terminals of the rat. Methods and Results: Rats placed on a diet that maintained blood levels of 30 mM EtOH for 20 to 40 days developed tolerance to acute EtOH inhibition of release. In the presence of 10 mM EtOH, high (50 mM) K-induced release of AVP from isolated neurohypophysial terminals of EtOH-naive rats was reduced by 77.7 ± 1.4%, whereas in the chronic EtOH group, release was reduced by only 9.4 ± 8.7%. Similar tolerance was evident during acute challenge with 75 mM EtOH, as well as for release of OT from isolated terminals. Animals treated with an intraperitoneal injection of EtOH and sacrificed 90 min postinjection did not exhibit the reduced EtOH inhibition of release from dissociated terminals during a 75 mM EtOH acute challenge. Conclusions: The altered component responsible for the tolerance to inhibition of release resides in the isolated terminal, because tolerance measured in vitro from intact neurohypophyses was similar to that seen in isolated terminals. The failure of EtOH-injected animals to exhibit reduced inhibition of release in response to an acute EtOH challenge indicates that short-term elevated blood alcohol level does not induce this tolerance. The finding of tolerance to EtOH- induced inhibition of release from the intact neurohypophysis and isolated terminals provides a physiological preparation in which to examine the molecular targets of acute drug action modified after chronic exposure to the drug.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033861709&origin=inward; http://dx.doi.org/10.1097/00000374-200007000-00020; http://doi.wiley.com/10.1097/00000374-200007000-00020; http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1097%2F00000374-200007000-00020; https://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2000.tb04653.x; http://dx.doi.org/10.1111/j.1530-0277.2000.tb04653.x; https://dx.doi.org/10.1111/j.1530-0277.2000.tb04653.x; https://dx.doi.org/10.1097/00000374-200007000-00020
Wiley
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know