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Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C.

The American journal of gastroenterology, ISSN: 0002-9270, Vol: 97, Issue: 3, Page: 714-20
2002
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Metric Options:   Counts1 Year3 Year

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Article Description

Hepatitis C virus (HCV) is the major causal agent of non-A, non-B hepatitis and the leading indication for liver transplantation worldwide. The emerging field of immunogenetics has confirmed the significant role of heritability in host immune responses to infectious pathogens. Both the major and non-major histocompatibility complex genes are increasingly identified as candidate genes hypothesized to influence the susceptibility to, or the course of, a particular disease. We hypothesized that polymorphisms within the major histocompatibility complex class III region that encode for tumor necrosis factors (TNF)-alpha and TNF-beta might be predictive of response to antiviral therapy in patients with chronic hepatitis C.

Bibliographic Details

Rosen, Hugo R; McHutchison, John G; Conrad, Andrew J; Lentz, Jennifer J; Marousek, Gail; Rose, Steven L; Zaman, Atif; Taylor, Kent; Chou, Sunwen

Ovid Technologies (Wolters Kluwer Health)

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