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Adsorptive depletion of elevated proinflammatory CD14CD16 DR monocytes in patients with inflammatory bowel disease

American Journal of Gastroenterology, ISSN: 0002-9270, Vol: 103, Issue: 5, Page: 1210-1216
2008
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Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast

STUDY INFORMATION OFFICIAL TITLE: An Investigator Initiated Study of Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast CURRENT STATUS: Recruiting STUDY

Article Description

BACKGROUND: In human blood, two monocyte populations exist, CD14 CD16 classical monocytes and CD14CD16 proinflammatory monocytes, which account for about 10% of total monocytes, but can expand to promote inflammatory conditions. CD14 CD16 monocytes produce large amounts of inflammatory cytokines including TNF-α and IL-1. Adacolumn adsorptive carriers adsorb from the blood in the column most of the monocytes/macrophages and granulocytes and this has been associated with clinical efficacy in patients with active inflammatory bowel disease (IBD). This study was to investigate the CD14 CD16 monocyte profile in patients with IBD and the impact of Adacolumn on this proinflammatory phenotype. METHODS: A total of 58 patients with ulcerative colitis (UC, N = 37) or Crohn's disease (CD, N = 21) together with 11 healthy controls were included in this study. Peripheral blood CD14CD16 monocytes were determined by three-color immunofluorescence and flow cytometry. RESULTS: The percentage of CD14 CD16 monocytes in patients with active CD was significantly (P = 0.0089) higher than the level in the control group, in patients with quiescent CD (P = 0.0419) or quiescent UC (P = 0.0063). Further, the percentage of CD14CD16 monocytes in patients with active UC who were on prednisolone (PSL) was less than the level in those not on PSL (P < 0.0001), thus PSL might have a suppressive effect on CD14 CD16 monocytes. Patients with active IBD were each given up to 10 Adacolumn granulocye/monocyte adsorption (GMA) sessions over an 8-wk period. The percentage of CD14CD16 monocytes decreased dramatically (P = 0.0077 in UC and P = 0.0117 in CD) compared with entry levels. CONCLUSIONS: A significant reduction in peripheral CD14CD16 monocytes by GMA should mitigate the inflammatory drive and contribute to the clinical efficacy of this procedure. Reduction of CD14 CD16 monocytes by corticosteroids was also seen. Hence, corticosteroids should enhance the efficacy of GMA. This is the first report on CD14CD16 monocytes being decreased by Adacolumn GMA in patients with IBD. © 2008 by Am. Coll. of Gastroenterology.

Bibliographic Details

Hanai, Hiroyuki; Iida, Takayuki; Takeuchi, Ken; Watanabe, Fumitoshi; Yamada, Masami; Kikuyama, Masataka; Maruyama, Yasushi; Iwaoka, Yasushi; Hirayama, Kazuhisa; Nagata, Seiji; Takai, Kenji

Ovid Technologies (Wolters Kluwer Health)

Medicine

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