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Major Challenges Limiting Liver Transplantation in the United States

American Journal of Transplantation, ISSN: 1600-6135, Vol: 11, Issue: 9, Page: 1773-1784
2011
  • 151
    Citations
  • 0
    Usage
  • 89
    Captures
  • 1
    Mentions
  • 5
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    151
  • Captures
    89
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    5
    • Shares, Likes & Comments
      5
      • Facebook
        5

Most Recent News

Clinical Validation of a Raman Spectroscope to Determine Hepatic Fat Content

STUDY INFORMATION OFFICIAL TITLE: Clinical Validation of High Throughput Raman Fiber Optic Probe to Determine Hepatic Fat Content CURRENT STATUS: Unknown status STUDY TYPE: Interventional

Review Description

Liver transplantation is the gold standard of care in patients with end-stage liver disease and those with tumors of hepatic origin in the setting of liver dysfunction. From 1988 to 2009, liver transplantation in the United States grew 3.7-fold from 1713 to 6320 transplants annually. The expansion of liver transplantation is chiefly driven by scientific breakthroughs that have extended patient and graft survival well beyond those expected 50 years ago. The success of liver transplantation is now its primary obstacle, as the pool of donor livers fails to keep pace with the growing number of patients added to the national liver transplant waiting list. This review focuses on three major challenges facing liver transplantation in the United States and discusses new areas of investigation that address each issue: (1) the need for an expanded number of useable donor organs, (2) the need for improved therapies to treat recurrent hepatitis C after transplantation and (3) the need for improved detection, risk stratification based upon tumor biology and molecular inhibitors to combat hepatocellular carcinoma.

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