Bremelanotide: An Overview of Preclinical CNS Effects on Female Sexual Function
The Journal of Sexual Medicine, ISSN: 1743-6095, Vol: 4, Issue: SUPPL. 4, Page: 269-279
2007
- 80Citations
- 55Captures
- 4Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations80
- Citation Indexes80
- 80
- CrossRef75
- Captures55
- Readers55
- 55
- Mentions4
- News Mentions2
- News2
- Blog Mentions1
- Blog1
- References1
- Wikipedia1
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Article Description
Bremelanotide is an analogue of the naturally occurring peptide α-melanocyte-stimulating hormone (α-MSH). It stimulates erection in men and male rats, and is currently in clinical trials for the treatment of erectile dysfunction. To review the effects of bremelanotide, an analogue of the naturally occurring peptide α-MSH, on the preclinical indices of sexual desire in female rats, and where in the brain these actions may occur. Appetitive sexual behaviors, such as solicitations, hops and darts, and pacing, were assessed along with consummatory behaviors such as lordosis. The involvement of brain regions was assessed following direct administration to the region, by the stimulation of molecular markers of neural activation, and using microdialysis to examine extracellular fluid for different neurotransmitters. Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors. Bremelanotide dramatically and selectively increased measures of solicitation in female rats, without altering pacing or lordosis, following both peripheral (subcutaneous) administration or infusions directly into the lateral ventricles or medial preoptic area (mPOA), but not the ventromedial hypothalamus. The mPOA is critical for the display of appetitive sexual behaviors in females and males of a variety of species. Peripheral administration of bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior, and may work by activating dopamine terminals in the mPOA. To the extent that solicitations indicate the desire of female rats to engage in sexual activity, bremelanotide appears to possess the behavioral, pharmacological, and neuroanatomical specificity required of a drug in the treatment of hypoactive sexual desire disorders. Pfaus J, Giuliano F, and Gelez H. Bremelanotide: An overview of preclinical CNS effects on female sexual function.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1743609515317793; http://dx.doi.org/10.1111/j.1743-6109.2007.00610.x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=35648941292&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17958619; https://academic.oup.com/jsm/article/4/Supplement_4/269/6889685; https://dx.doi.org/10.1111/j.1743-6109.2007.00610.x; https://academic.oup.com/jsm/article-abstract/4/Supplement_4/269/6889685?redirectedFrom=fulltext
Oxford University Press (OUP)
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