Some factors influencing the metabolism of benzylamine by type A and B monoamine oxidase in rat heart and liver
Journal of Pharmacy and Pharmacology, ISSN: 2042-7158, Vol: 32, Issue: 1, Page: 844-850
1980
- 41Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations41
- Citation Indexes41
- 41
- CrossRef38
- Captures2
- Readers2
Article Description
The ability of MAO‐A and MAO‐B to metabolize benzylamine in vitro has been investigated in mitochondrial preparations from rat liver and heart. Although under normal circumstances benzylamine appeared to be metabolized exclusively by MAO‐B in the rat liver, a contribution by both MAO‐A and a clorgyline‐resistant enzyme component was revealed when the MAO‐B activity was much reduced by pretreatment of the mitochondria with appropriate concentrations of deprenyl. These three enzyme activities also contributed to benzylamine deamination in rat heart mitochondria. However, binding studies with [ H]pargyline, which provided an estimate of the respective concentrations of MAO‐A and MAO‐B active centres in heart mitochondria, indicated a ratio between MAO‐A and MAO‐B, markedly different from that shown by plots of inhibition of benzylamine metabolism by various concentrations of clorgyline. The interpretation of these clorgyline plots is discussed in terms of the kinetic constants of both MAO‐A and MAO‐B, and the relative amounts of each enzyme. It is proposed that although the turnover rate constant for benzylamine metabolism by MAO‐A is much smaller than that shown by MAO‐B, in those tissues containing a large ratio of MAO‐A:MAO‐B content, the metabolism of benzylamine by MAO‐A can be detected. 1980 Royal Pharmaceutical Society of Great Britain
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019254011&origin=inward; http://dx.doi.org/10.1111/j.2042-7158.1980.tb13088.x; http://www.ncbi.nlm.nih.gov/pubmed/6110749; https://academic.oup.com/jpp/article/32/1/844/6198819; https://dx.doi.org/10.1111/j.2042-7158.1980.tb13088.x; https://academic.oup.com/jpp/article-abstract/32/1/844/6198819?redirectedFrom=fulltext
Oxford University Press (OUP)
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