Antiviral and immunomodulatory effects of a novel bacterial exopolysaccharide of shallow marine vent origin
Journal of Applied Microbiology, ISSN: 1365-2672, Vol: 116, Issue: 4, Page: 1028-1034
2014
- 56Citations
- 56Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations56
- Citation Indexes56
- 56
- CrossRef47
- Captures56
- Readers56
- 55
- Mentions1
- News Mentions1
- 1
Most Recent News
EPS T14 from Bacillus licheniformis Prevents Infection of Human Nasal Epithelial Cells by Respiratory Viruses
Introduction Despite successes of preventive measures and vaccinations, respiratory tract viral infections still have a significant impact on morbidity and mortality worldwide causing seasonal epidemics
Article Description
Aims: To evaluate a novel exopolysaccharide (EPS1) from the recently described haloalkaliphilic, thermophilic Bacillus licheniformis strain T14, isolated from a shallow hydrothermal vent of Panarea Island (Italy), for its antiviral and immunomodulatory effects against herpes simplex virus type 2 (HSV-2). Methods and Results: EPS1-T14 hindered the HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells, indicating that cell-mediated immunity was involved in the antiviral activity. High levels of Th1-type cytokines were detected in supernatants of EPS1-treated PBMC, while Th2-type cytokines were not induced. Conclusions: The novel EPS1-T14 is a water-soluble, noncytotoxic exopolymer able to stimulate the immune response and thus contribute to the antiviral immune defence, acting as immunomodulator. Significance and Impact of the Study: The exopolysaccharide produced by B. licheniformis strain T14, stimulator of Th1 cell-mediated immunity, could be used as therapy in immunocompromised host. © 2013 The Society for Applied Microbiology.
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