Quercetin loaded nanostructured lipid carrier for food fortification: Preparation, characterization and in vitro study
Journal of Food Process Engineering, ISSN: 1745-4530, Vol: 38, Issue: 1, Page: 93-106
2015
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Article Description
Nanostructured lipid carriers (NLC) have been developed for encapsulation of bioactive flavonoids such as quercetin (QT). In this study, QT-NLC was prepared by high-pressure homogenization method. For the optimized QT-NLC, the average particle size, the zeta potential and the average entrapment efficiency were 129 ± 12.13 nm, -26 ± 4 mV and 93.50 ± 0.35%, respectively. The developed QT-NLC had good physical stability at ambient temperature condition. In vitro antioxidant activities assays showed comparable antioxidant activity of QT-NLC to free QT. Fourier transform-infrared spectroscopy analysis of QT-NLC confirmed encapsulation of QT in NLC and no chemical interaction between QT and lipid matrix. Lyophilization was proved feasible for the storage of QT-NLC dispersion. The in vitro release study in simulated gastrointestinal fluids showed a sustained release profile of QT-NLC. The release of the QT-NLC in simulated gastric fluids and simulated intestinal fluids was best fitted to Higuchi and Rigter-Peppas model, respectively. The gastrointestinal tract model indicated that the bioaccessibility of QT within simulated small intestinal conditions was improved by encapsulation. The QT-NLC also showed potential application in soft beverage. Particle size remained relatively steady in simulated beverage solutions for 2 months. It demonstrated that nanostructure lipid carriers could be designed as delivery system for encapsulation of bioactive compounds and applied in functional food industries.
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