Bilirubin is an independent factor inversely associated with glycated hemoglobin level in pediatric patients with type 1 diabetes
Pediatric Diabetes, ISSN: 1399-5448, Vol: 15, Issue: 5, Page: 389-393
2014
- 11Citations
- 25Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef7
- Captures25
- Readers25
- 25
Article Description
Objective: Bilirubin is a potent antioxidant, and serum total bilirubin (STB) concentrations correlate negatively with cardiovascular risk. In adult diabetic patients and in healthy adults, a negative correlation between STB and glycated hemoglobin (HbA1c) has been reported. We investigated whether there is such an association in children and adolescents with type 1 diabetes mellitus. Methods: The study group included 224 patients with type 1 diabetes duration of more than 12months. Patients with suspected or confirmed hemolytic anemia or liver dysfunction were excluded. Results: A statistically significant negative correlation was found between STB and HbA1c (R=-0.15; p=0.024), which retained its significance in multivariate analysis (β=-0.18, p=0.005). Patients' age and daily insulin dose were positively correlated with HbA1c levels, whereas other variables included in the multivariate analysis [sex, diabetes duration, insulin regimen, C-peptide, hemoglobin, mean corpuscular hemoglobin concentration (MCHC), alanine transaminase (ALT), and aspartate transaminase (AST)] did not correlate with HbA1c. The mean HbA1c level in patients with STB >1.2mg/dL (>21μmol/L; the threshold for clinical diagnosis of Gilbert's syndrome) was lower than in patients with STB ≤1.2mg/dL (≤21μmol/L), and the mean difference was 0.63% (6.9mmol/mol; 95% CI: 0.11-1.16%). Conclusions: These results show that in young patients with type 1 diabetes, STB concentration is an independent factor inversely associated with HbA1c level. Further studies should investigate the background and long-term effects of this association. © 2013 John Wiley & Sons A/S.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904465631&origin=inward; http://dx.doi.org/10.1111/pedi.12102; http://www.ncbi.nlm.nih.gov/pubmed/24350700; https://onlinelibrary.wiley.com/doi/10.1111/pedi.12102; http://doi.wiley.com/10.1111/pedi.12102; http://onlinelibrary.wiley.com/doi/10.1111/pedi.12102/abstract
Hindawi Limited
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