Nano-Advantage in Enhanced Drug Delivery with Biodegradable Nanoparticles: Contribution of Reduced Clearance
Drug Metabolism and Disposition, ISSN: 0090-9556, Vol: 40, Issue: 7, Page: 1380-1388
2012
- 127Citations
- 204Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations127
- Citation Indexes127
- 127
- CrossRef126
- Captures204
- Readers204
- 204
- Mentions2
- News Mentions2
- 2
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Formulation, optimization, characterization and evaluation of Simvastatin loaded solid lipid nanoparticles using quality by design approach
Katkade P.N.1, Zalte A. G.2, Gondkar S. B.3, Darekar A. B.4, Amrutkar S. V.1 (1) Department of Pharmaceutics, Sir Dr. M. S. Gosavi College of
Article Description
The aim of this study was to investigate the contribution of reduced apparent clearance to the enhanced exposure reported for biodegradable nanoparticles after extravascular and intravascular routes of administration. Plasma concentration profiles for drug and nanoparticle formulations after administration by intravenous, intraduodenal, and oral routes were extracted from the literature. Data were fit to pharmacokinetic models using BOOMER. The compartmental pharmacokinetic analysis of literature data for six drugs (camptothecin, 9-nitrocamptothecin, epirubicin, vinpocetine, clozapine, and cyclosporine) showed that the encapsulation of drug molecules in nanoparticles significantly reduced the apparent clearance and prolonged the apparent circulation half-life compared with those for the plain drug. Positively charged nanoparticles assessed in this study had lower apparent clearance, lower elimination rate constant values, and longer apparent circulation half-life than neutral and negatively charged nanoparticles. After oral administration, a reduction in apparent clearance contributed substantially to elevations in plasma drug exposure with nanoparticles. For the drugs and delivery systems examined, the nano-advantage in drug delivery enhancement can be explained, in part, by reduced clearance.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0090955624227318; http://dx.doi.org/10.1124/dmd.112.044925; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862660378&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22498894; https://linkinghub.elsevier.com/retrieve/pii/S0090955624227318; https://dx.doi.org/10.1124/dmd.112.044925; https://dmd.aspetjournals.org/content/40/7/1380
Elsevier BV
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