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Nano-Advantage in Enhanced Drug Delivery with Biodegradable Nanoparticles: Contribution of Reduced Clearance

Drug Metabolism and Disposition, ISSN: 0090-9556, Vol: 40, Issue: 7, Page: 1380-1388
2012
  • 127
    Citations
  • 0
    Usage
  • 204
    Captures
  • 2
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    127
  • Captures
    204
  • Mentions
    2
    • News Mentions
      2
      • 2
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

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Katkade P.N.1, Zalte A. G.2, Gondkar S. B.3, Darekar A. B.4, Amrutkar S. V.1 (1) Department of Pharmaceutics, Sir Dr. M. S. Gosavi College of

Article Description

The aim of this study was to investigate the contribution of reduced apparent clearance to the enhanced exposure reported for biodegradable nanoparticles after extravascular and intravascular routes of administration. Plasma concentration profiles for drug and nanoparticle formulations after administration by intravenous, intraduodenal, and oral routes were extracted from the literature. Data were fit to pharmacokinetic models using BOOMER. The compartmental pharmacokinetic analysis of literature data for six drugs (camptothecin, 9-nitrocamptothecin, epirubicin, vinpocetine, clozapine, and cyclosporine) showed that the encapsulation of drug molecules in nanoparticles significantly reduced the apparent clearance and prolonged the apparent circulation half-life compared with those for the plain drug. Positively charged nanoparticles assessed in this study had lower apparent clearance, lower elimination rate constant values, and longer apparent circulation half-life than neutral and negatively charged nanoparticles. After oral administration, a reduction in apparent clearance contributed substantially to elevations in plasma drug exposure with nanoparticles. For the drugs and delivery systems examined, the nano-advantage in drug delivery enhancement can be explained, in part, by reduced clearance.

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