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Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5

Science Advances, ISSN: 2375-2548, Vol: 9, Issue: 38, Page: eadj1736
2023
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Researchers at Cornell University Target COVID-19 (Age-dependent Acquisition of Pathogenicity By Sars-cov-2 Omicron Ba.5)

2023 NOV 07 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Daily -- Current study results on Coronavirus - COVID-19 have been

Article Description

Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the lack of pathogenic animal models. While Omicron BA.1 and BA.2 replicate in K18-hACE2 transgenic mice, they cause minimal to negligible morbidity and mortality, and less is known about more recent Omicron VOC. Here, we show that in contrast to Omicron BA.1, BA.5-infected mice exhibited high levels of morbidity and mortality, correlating with higher early viral loads. Neither Omicron BA.1 nor BA.5 replicated in brains, unlike most prior VOC. Only Omicron BA.5–infected mice exhibited substantial weight loss, high pathology scores in lungs, and high levels of inflammatory cells and cytokines in bronchoalveolar lavage fluid, and 5- to 8-month-old mice exhibited 100% fatality. These results identify a rodent model for pathogenesis or antiviral countermeasure studies for circulating SARS-CoV-2 Omicron BA.5. Further, differences in morbidity and mortality between Omicron BA.1 and BA.5 provide a model for understanding viral determinants of pathogenicity.

Bibliographic Details

Imbiakha, Brian; Ezzatpour, Shahrzad; Buchholz, David W; Sahler, Julie; Ye, Chengjin; Olarte-Castillo, Ximena A; Zou, Anna; Kwas, Cole; O'Hare, Katelyn; Choi, Annette; Adeleke, Richard Ayomide; Khomandiak, Solomiia; Goodman, Laura; Jager, Mason C; Whittaker, Gary R; Martinez-Sobrido, Luis; August, Avery; Aguilar, Hector C

American Association for the Advancement of Science (AAAS)

Multidisciplinary

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