Structure of the immature dengue virus at low pH primes proteolytic maturation
Science, ISSN: 0036-8075, Vol: 319, Issue: 5871, Page: 1834-1837
2008
- 516Citations
- 576Captures
- 3Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations516
- Citation Indexes515
- 515
- CrossRef500
- Policy Citations1
- Policy Citation1
- Captures576
- Readers576
- 576
- Mentions3
- References2
- Wikipedia2
- News Mentions1
- News1
Most Recent News
Anticuerpos contra el virus del dengue en pacientes con dislipidemias /Antibodies against dengue virus in patients with dislipidemias.
Introducción Los virus son agentes patógenos intracelulares obligados que dependen del metabolismo de la célula huésped para su replicación; interactúan con las membranas y los
Article Description
Intracellular cleavage of immature flaviviruses is a critical step in assembly that generates the membrane fusion potential of the E glycoprotein. With cryo-electron microscopy we show that the immature dengue particles undergo a reversible conformational change at low pH that renders them accessible to furin cleavage. At a pH of 6.0, the E proteins are arranged in a herringbone pattern with the pr peptides docked onto the fusion loops, a configuration similar to that of the mature virion. After cleavage, the dissociation of pr is pH-dependent, suggesting that in the acidic environment of the trans-Golgi network pr is retained on the virion to prevent membrane fusion. These results suggest a mechanism by which flaviviruses are processed and stabilized in the host cell secretory pathway.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41349112304&origin=inward; http://dx.doi.org/10.1126/science.1153264; http://www.ncbi.nlm.nih.gov/pubmed/18369148; https://www.science.org/doi/10.1126/science.1153264; https://dx.doi.org/10.1126/science.1153264; https://www.science.org/lookup/doi/10.1126/science.1153264
American Association for the Advancement of Science (AAAS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know