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Pre-Bötzinger complex: A brainstem region that may generate respiratory rhythm in mammals

Science, ISSN: 0036-8075, Vol: 254, Issue: 5032, Page: 726-729
1991
  • 1,785
    Citations
  • 0
    Usage
  • 520
    Captures
  • 16
    Mentions
  • 17
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,785
    • Citation Indexes
      1,784
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    520
  • Mentions
    16
    • References
      8
      • Wikipedia
        8
    • News Mentions
      7
      • News
        7
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    17
    • Shares, Likes & Comments
      17
      • Facebook
        17

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Article Description

The location of neurons generating the rhythm of breathing in mammals is unknown. By microsection of the neonatal rat brainstem in vitro, a limited region of the ventral medulla (the pre-Bötzinger Complex) that contains neurons essential for rhythmogenesis was identified. Rhythm generation was eliminated by removal of only this region. Medullary slices containing die pre-Bötzinger Complex generated respiratory-related oscillations similar to those generated by the whole brainstem in vitro, and neurons with voltage-dependent pacemaker-like properties were identified in this region. Thus, the respiratory rhythm in the mammalian neonatal nervous system may result from a population of conditional bursting pacemaker neurons in the pre-Bötzinger Complex.

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