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A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma- associated herpesvirus

Science, ISSN: 0036-8075, Vol: 277, Issue: 5332, Page: 1656-1659
1997
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Article Description

Kaposi's sarcoma-associated herpesvirus encodes a chemokine called vMIP- II. This protein displayed a broader spectrum of receptor activities than any mammalian chemokine as it bound with high affinity to a number of both CC and CXC chemokine receptors. Binding of vMIP-II, however, was not associated with the normal, rapid mobilization of calcium from intracellular stores; instead, it blocked calcium mobilization induced by endogenous chemokines. In freshly isolated human monocytes the virally encoded vMIP-II acted as a potent and efficient antagonist of chemotaxis induced by chemokines. Because vMIP-II could inhibit cell entry of human immunodeficiency virus (HIV) mediated through CCR3 and CCR5 as well as CXCR4, this protein may serve as a lead for development of broad-spectrum anti-HIV agents.

Bibliographic Details

Thomas N. Kledal; Mette M. Rosenkilde; Florence Coulin; Graham Simmons; Anders H. Johnsen; Sami Alouani; Christine A. Power; Hans R. Lüttichau; Jan Gerstoft; Paul R. Clapham; Ian Clark-Lewis; Timothy N. C. Wells; Thue W. Schwartz

American Association for the Advancement of Science (AAAS)

Multidisciplinary

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