Loss of insulator activity by paired Su(Hw) chromatin insulators
Science, ISSN: 0036-8075, Vol: 291, Issue: 5503, Page: 495-498
2001
- 175Citations
- 83Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations175
- Citation Indexes175
- 175
- CrossRef154
- Captures83
- Readers83
- 83
Article Description
Chromatin insulators are regulatory elements that block the action of transcriptional enhancers when interposed between enhancer and promoter. The Drosophila Suppressor of Hairy wing [Su(Hw)] protein binds the Su(Hw) insulator and prevents enhancer-promoter interaction by a mechanism that is not understood. We show that when two copies of the Su(Hw) insulator element, instead of a single one, are inserted between enhancer and promoter, insulator activity is neutralized and the enhancer-promoter interaction may instead be facilitated. This paradoxical phenomenon could be explained by interactions between protein complexes bound at the insulators.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035910493&origin=inward; http://dx.doi.org/10.1126/science.291.5503.495; http://www.ncbi.nlm.nih.gov/pubmed/11161206; https://www.science.org/doi/10.1126/science.291.5503.495; https://dx.doi.org/10.1126/science.291.5503.495; https://www.science.org/lookup/doi/10.1126/science.291.5503.495
American Association for the Advancement of Science (AAAS)
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