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Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: Evidence for decreased sensitivity to dormancy and growth inhibition

Antimicrobial Agents and Chemotherapy, ISSN: 0066-4804, Vol: 56, Issue: 1, Page: 428-431
2012
  • 54
    Citations
  • 0
    Usage
  • 67
    Captures
  • 0
    Mentions
  • 20
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    54
  • Captures
    67
  • Social Media
    20
    • Shares, Likes & Comments
      20
      • Facebook
        20

Article Description

The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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