Immunomodulatory effect of zidovudine (ZDV) on cytotoxic T lymphocytes previously exposed to ZDV
Antimicrobial Agents and Chemotherapy, ISSN: 0066-4804, Vol: 46, Issue: 9, Page: 2865-2871
2002
- 3Citations
- 4Captures
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef1
- Captures4
- Readers4
Article Description
In a previous study, zidovudine (ZDV) was shown to cause a concentration-dependent inhibition of antigen-specific cytotoxic T-lymphocyte (CTL) clonal expansion (S. Francke, C. G. Orosz, K. A. Hayes, and L. E. Mathes, Antimicrob. Agents Chemother. 44:1900-1905, 2000). However, this suppressive effect was lost if exposure to ZDV was delayed for 24 to 48 h during the antigen sensitization period, suggesting that antigen-primed CTL may be less susceptible than naive T lymphocytes to the suppressive effects of ZDV. The present study was undertaken to determine if naive T lymphocytes were more sensitive to the suppressive effects of ZDV than T lymphocytes previously exposed to antigen. The 50% inhibitory concentration (IC) values of ZDV were determined on naive and antigen-primed T-cell responses in an alloantigen system. Lymphocyte cultures with continuous antigen exposure (double prime) were more resistant to ZDV suppression (IC = 316 μM) than were naive lymphocytes (IC = 87.5 μM). Interestingly, lymphocytes that were antigen primed but deprived of antigen during the final 7 days of culture (prime/hold) were exquisitely sensitive to ZDV suppression (IC = 29.3 μM). The addition of 80 μM ZDV during the initial priming of the single-prime (prime/hold) and double-prime cultures did not select for a more drug-resistant cell population. The differences in ZDV sensitivities are likely a reflection of the physiological properties of the lymphocytes related to their activation state.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036720651&origin=inward; http://dx.doi.org/10.1128/aac.46.9.2865-2871.2002; http://www.ncbi.nlm.nih.gov/pubmed/12183239; https://journals.asm.org/doi/10.1128/AAC.46.9.2865-2871.2002; http://aac.asm.org/cgi/doi/10.1128/AAC.46.9.2865-2871.2002; https://syndication.highwire.org/content/doi/10.1128/AAC.46.9.2865-2871.2002; https://dx.doi.org/10.1128/aac.46.9.2865-2871.2002
American Society for Microbiology
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