A host of issues: pseudoreplication in host-microbiota studies
Applied and environmental microbiology, ISSN: 1098-5336, Vol: 90, Issue: 8, Page: e0103324-null
2024
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Most Recent News
Researchers at Southeast Missouri State University Release New Data on Applied and Environmental Microbiology (A Host of Issues: Pseudoreplication In Host-microbiota Studies)
2024 AUG 27 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Investigators publish new report on Life Sciences -
Review Description
Pseudoreplication compromises the validity of research by treating non-independent samples as independent replicates. This review examines the prevalence of pseudoreplication in host-microbiota studies, highlighting the critical need for rigorous experimental design and appropriate statistical analysis. We systematically reviewed 115 manuscripts on host-microbiota interactions. Our analysis revealed that 22% of the papers contained pseudoreplication, primarily due to co-housed organisms, whereas 52% lacked sufficient methodological details. The remaining 26% adequately addressed pseudoreplication through proper experimental design or statistical analysis. The high incidence of pseudoreplication and insufficient information underscores the importance of methodological reporting and statistical rigor to ensure reproducibility of host-microbiota research.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85201993678&origin=inward; http://dx.doi.org/10.1128/aem.01033-24; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85201750644&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/39082810; https://journals.asm.org/doi/10.1128/aem.01033-24
American Society for Microbiology
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