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Human papillomavirus and cervical cancer

Clinical Microbiology Reviews, ISSN: 0893-8512, Vol: 16, Issue: 1, Page: 1-17
2003
  • 1,405
    Citations
  • 0
    Usage
  • 2,049
    Captures
  • 16
    Mentions
  • 235
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,405
    • Citation Indexes
      1,399
    • Policy Citations
      4
      • 4
    • Patent Family Citations
      2
      • 2
  • Captures
    2,049
  • Mentions
    16
    • News Mentions
      16
      • 16
  • Social Media
    235
    • Shares, Likes & Comments
      235
      • Facebook
        235

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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer

Introduction Cervical carcinoma is one of the most common gynecological cancers worldwide, accounting for approximately 12% of all carcinomas in women.1 It originates from abnormal

Review Description

Of the many types of human papillomavirus (HPV), more than 30 infect the genital tract. The association between certain oncogenic (high-risk) strains of HPV and cervical cancer is well established. Although HPV is essential to the transformation of cervical epithelial cells, it is not sufficient, and a variety of cofactors and molecular events influence whether cervical cancer will develop. Early detection and treatment of precancerous lesions can prevent progression to cervical cancer. Identification of precancerous lesions has been primarily by cytologic screening of cervical cells. Cellular abnormalities, however, may be missed or may not be sufficiently distinct, and a portion of patients with borderline or mildly dyskaryotic cytomorphology will have higher-grade disease identified by subsequent colposcopy and biopsy. Sensitive and specific molecular techniques that detect HPV DNA and distinguish high-risk HPV types from low-risk HPV types have been introduced as an adjunct to cytology. Earlier detection of high-risk HPV types may improve triage, treatment, and follow-up in infected patients. Currently, the clearest role for HPV DNA testing is to improve diagnostic accuracy and limit unnecessary colposcopy in patients with borderline or mildly abnormal cytologic test results.

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