Human macrophage gamma interferon decreases gene expression but not replication of Mycobacterium tuberculosis: Analysis of the host-pathogen reciprocal influence on transcription in a comparison of strains H37Rv and CMT97
Infection and Immunity, ISSN: 0019-9567, Vol: 69, Issue: 12, Page: 7262-7270
2001
- 35Citations
- 38Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations35
- Citation Indexes35
- 35
- CrossRef25
- Captures38
- Readers38
- 38
Article Description
Mycobacterium tuberculosis is an intracellular pathogen that readily survives and replicates in human macrophages (Mφ). Host cells have developed different mycobactericidal mechanisms, including the production of inflammatory cytokines. The aim of this study was to compare the Mφ response, in terms of cytokine gene expression, to infection with the M. tuberculosis laboratory strain H37Rv and the clinical M. tuberculosis isolate CMT97. Both strains induce the production of interleukin-12 (IL-12) and IL-16 at comparable levels. However, the clinical isolate induces a significantly higher and more prolonged Mφ activation, as shown by reverse transcription-PCR analysis of IL-1β, IL-6, IL-10, transforming growth factor beta, tumor necrosis factor alpha, and gamma interferon (IFN-γ) transcripts. Interestingly, when IFN-γ transcription is high, the number of M. tuberculosis genes expressed decreases and vice versa, whereas no mycobactericidal effect was observed in terms of bacterial growth. Expression of 11 genes was also studied in the two M. tuberculosis strains by infecting resting or activated Mφ and compared to bacterial intracellular survival. In both cases, a peculiar inverse correlation between expression of these genes and multiplication was observed. The number and type of genes expressed by the two strains differed significantly.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035191662&origin=inward; http://dx.doi.org/10.1128/iai.69.12.7262-7270.2001; http://www.ncbi.nlm.nih.gov/pubmed/11705896; http://iai.asm.org/cgi/doi/10.1128/IAI.69.12.7262-7270.2001; https://syndication.highwire.org/content/doi/10.1128/IAI.69.12.7262-7270.2001; https://journals.asm.org/doi/10.1128/IAI.69.12.7262-7270.2001; https://dx.doi.org/10.1128/iai.69.12.7262-7270.2001
American Society for Microbiology
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