Expression of Kingella kingae type IV pili is regulated by σ, PilS, and PilR
Journal of Bacteriology, ISSN: 0021-9193, Vol: 191, Issue: 15, Page: 4976-4986
2009
- 52Citations
- 88Usage
- 35Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef42
- Usage88
- Downloads88
- Captures35
- Readers35
- 35
- Mentions1
- References1
- Wikipedia1
Article Description
Kingella kingae is a member of the Neisseriaceae and is being recognized increasingly as an important cause of serious disease in children. Recent work has demonstrated that K. kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells and are selected against during invasive disease. In the current study, we examined the genome of K. kingae strain 269-492 and identified homologs of the rpoN and the pilS and pilR genes that are essential for pilus expression in Pseudomonas aeruginosa but not in the pathogenic Neisseria species. The disruption of either rpoN or pilR in K. kingae resulted in a marked reduction in the level of transcript for the major pilus subunit (pilA1) and eliminated piliation. In contrast, the disruption of pilS resulted in only partial reduction in the level of pilA1 transcript and a partial decrease in piliation. Furthermore, the disruption of pilS in colony variants with high-density piliation resulted in variants with low-density piliation. Mutations in the promoter region of pilA1 and gel shift analysis demonstrated that both σ and PilR act directly at the pilA1 promoter, with PilR binding to two repetitive elements. These data suggest that the regulation of K. kingae type IV pilus expression is complex and multilayered, influenced by both the genetic state and environmental cues. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67749127365&origin=inward; http://dx.doi.org/10.1128/jb.00123-09; http://www.ncbi.nlm.nih.gov/pubmed/19465661; https://journals.asm.org/doi/10.1128/JB.00123-09; http://jb.asm.org/cgi/doi/10.1128/JB.00123-09; https://syndication.highwire.org/content/doi/10.1128/JB.00123-09; https://digitalcommons.wustl.edu/open_access_pubs/2441; https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3444&context=open_access_pubs; https://dx.doi.org/10.1128/jb.00123-09; http://jb.asm.org/lookup/doi/10.1128/JB.00123-09; https://jb.asm.org/content/191/15/4976; https://jb.asm.org/content/191/15/4976.abstract; https://jb.asm.org/content/191/15/4976.full.pdf; https://journals.asm.org/doi/abs/10.1128/JB.00123-09; http://jb.asm.org/content/191/15/4976; https://jb.asm.org/content/jb/191/15/4976.full.pdf
American Society for Microbiology
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