Structural maturation of the transmissible gastroenteritis coronavirus
Journal of Virology, ISSN: 0022-538X, Vol: 73, Issue: 10, Page: 7952-7964
1999
- 60Citations
- 37Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations60
- Citation Indexes59
- 59
- CrossRef52
- Policy Citations1
- 1
- Captures37
- Readers37
- 37
Article Description
During the life cycle of the transmissible gastroenteritis coronavirus (TGEV), two types of virus-related particles are detected in infected swine testis cells: large annular viruses and small dense viruses. We have studied the relationships between these two types of particles. Immunoelectron microscopy showed that they are closely related, since both large and small particles reacted equally with polyclonal and monoclonal antibodies specific for TGEV proteins. Monensin, a drug that selectively affects the Golgi complex, caused an accumulation of large annular viral particles in perinuclear elements of the endoplasmic reticulum-Golgi intermediate compartment. A partial reversion of the monensin blockade was obtained in both the absence and presence of cycloheximide, a drug that prevented the formation of new viral particles. After removal of monensin, the Golgi complex recovered its perinuclear location, and a decrease in the number of perinuclear large viral particles was observed. The release of small dense viral particles into secretory vesicles and the extracellular medium was also observed, as was a partial recovery of infectivity in culture supernatants. Small viral particles started to be seen between the third and the fourth Golgi cisternae of normally infected cells. All of these data strongly indicate that the large annular particles are the immature precursors of the small dense viruses, which are the infectious TGEV virions. The immature viral particles need to reach a particular location at the trans side of the Golgi stack to complete their morphological maturation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032845105&origin=inward; http://dx.doi.org/10.1128/jvi.73.10.7952-7964.1999; http://www.ncbi.nlm.nih.gov/pubmed/10482542; https://journals.asm.org/doi/10.1128/JVI.73.10.7952-7964.1999; https://dx.doi.org/10.1128/jvi.73.10.7952-7964.1999; https://jvi.asm.org/content/73/10/7952
American Society for Microbiology
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