Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Molecular and Cellular Biology, ISSN: 0270-7306, Vol: 27, Issue: 21, Page: 7511-7521
2007
- 383Citations
- 236Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations383
- Citation Indexes382
- 382
- CrossRef323
- Patent Family Citations1
- Patent Families1
- Captures236
- Readers236
- 236
- Mentions1
- News Mentions1
- News1
Most Recent News
Targeting the AMPK/Nrf2 Pathway: A Novel Therapeutic Approach for Acute Lung Injury
Introduction As is well documented, acute lung injury (ALI) refers to hypoxaemic respiratory insufficiency resulting from various intrapulmonary and extrapulmonary causes. It is characterized by
Article Description
Nrf2 is the regulator of the oxidative/electrophilic stress response. Its turnover is maintained by Keap1-mediated proteasomal degradation via a two-site substrate recognition mechanism in which two Nrf2-Keap1 binding sites form a hinge and latch. The E3 ligase adaptor Keap1 recognizes Nrf2 through its conserved ETGE and DLG motifs. In this study, we examined how the ETGE and DLG motifs bind to Keap1 in a very similar fashion but with different binding affinities by comparing the crystal complex of a Keap1-DC domain-DLG peptide with that of a Keap1-DC domain-ETGE peptide. We found that these two motifs interact with the same basic surface of either Keap1-DC domain of the Keap1 homodimer. The DLG motif works to correctly position the lysines within the Nrf2 Neh2 domain for efficient ubiquitination. Together with the results from calorimetric and functional studies, we conclude that different electrostatic potentials primarily define the ETGE and DLG motifs as a hinge and latch that senses the oxidative electrophilic stress. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=35648970026&origin=inward; http://dx.doi.org/10.1128/mcb.00753-07; http://www.ncbi.nlm.nih.gov/pubmed/17785452; https://www.tandfonline.com/doi/full/10.1128/MCB.00753-07; http://mcb.asm.org/cgi/doi/10.1128/MCB.00753-07; https://syndication.highwire.org/content/doi/10.1128/MCB.00753-07; https://dx.doi.org/10.1128/mcb.00753-07; https://journals.asm.org/doi/10.1128/MCB.00753-07
Informa UK Limited
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know