Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin
Molecular and Cellular Biology, ISSN: 0270-7306, Vol: 30, Issue: 10, Page: 2518-2536
2010
- 95Citations
- 111Captures
- 2Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations95
- Citation Indexes94
- 94
- CrossRef90
- Policy Citations1
- Policy Citation1
- Captures111
- Readers111
- 111
- Mentions2
- News Mentions1
- News1
- References1
- Wikipedia1
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Article Description
Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal adult hair homeostasis (cycle) and blocks adult hair follicle stem cells (HFSCs) in quiescence. Here, we show that these effects are overcome later in adulthood. By deleting Runx1 after the end of morphogenesis, we demonstrate its direct role in promoting anagen onset and HFSC proliferation. Runx1 deletion resulted in cyclin-dependent kinase inhibitor Cdkn1a (p21) upregulation. Interfering with Runx1 function in cultured HFSCs impaired their proliferation and normal G /G1 and G/S cell cycle progression. The proliferation defect could be rescued by Runx1 readdition or by p21 deletion. Chemically induced skin tumorigenesis in mice turned on broad Runx1 expression in regions of the skin epithelium, papillomas, and squamous cell carcinomas. In addition, it revealed reduced rates of tumor formation in the absence of Runx1 that were accompanied by decreased epithelial levels of phospho-Stat3. Runx1 protein expression was similar in normal human and mouse hair cycles. We propose that Runx1 may act as a skin oncogene by directly promoting proliferation of the epithelial cells. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952005330&origin=inward; http://dx.doi.org/10.1128/mcb.01308-09; http://www.ncbi.nlm.nih.gov/pubmed/20308320; https://www.tandfonline.com/doi/full/10.1128/MCB.01308-09; http://mcb.asm.org/cgi/doi/10.1128/MCB.01308-09; https://syndication.highwire.org/content/doi/10.1128/MCB.01308-09; https://dx.doi.org/10.1128/mcb.01308-09; https://mcb.asm.org/content/30/10/2518; https://mcb.asm.org/content/30/10/2518.abstract; https://mcb.asm.org/content/mcb/30/10/2518.full.pdf; http://mcb.asm.org/lookup/doi/10.1128/MCB.01308-09; https://mcb.asm.org/content/30/10/2518.full.pdf; http://mcb.asm.org/content/30/10/2518; https://journals.asm.org/doi/10.1128/MCB.01308-09; https://journals.asm.org/doi/abs/10.1128/MCB.01308-09
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