A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2
Molecular and Cellular Biology, ISSN: 0270-7306, Vol: 31, Issue: 11, Page: 2287-2298
2011
- 54Citations
- 61Captures
- 5Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations54
- Citation Indexes54
- 54
- CrossRef44
- Captures61
- Readers61
- 61
- Mentions5
- References5
- 5
Article Description
We previously reported that expression of NRIF3 (nuclear receptor interacting factor-3) rapidly and selectively leads to apoptosis of breast cancer cells. DIF-1 (also known as interferon regulatory factor-2 binding protein 2 [IRF-2BP2]), the cellular target of NRIF3, was identified as a transcriptional repressor, and DIF-1 knockdown leads to apoptosis of breast cancer cells but not other cell types. Here, we identify IRF-2BP1 and EAP1 (enhanced at puberty 1) as important components of the DIF-1 complex mediating both complex stability and transcriptional repression. This interaction of DIF-1, IRF-2BP1, and EAP1 occurs through the conserved C4 zinc fingers of these proteins. Microarray studies were carried out in breast cancer cell lines engineered to conditionally and rapidly increase the levels of the death domain (DD1) region of NRIF3. The DIF-1 complex was found to repress FASTKD2, a putative proapoptotic gene, in breast cancer cells and to bind to the FASTKD2 gene by chromatin immunoprecipitation. FASTKD2 knockdown prevents apoptosis of breast cancer cells from NRIF3 expression or DIF-1 knockdown, while expression of FASTKD2 leads to apoptosis of both breast and nonbreast cancer cells. Thus, regulation of FASTKD2 by NRIF3 and the DIF-1 complex acts as a novel death switch that selectively modulates apoptosis in breast cancer. © 2011, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79958044076&origin=inward; http://dx.doi.org/10.1128/mcb.01381-10; http://www.ncbi.nlm.nih.gov/pubmed/21444724; https://www.tandfonline.com/doi/full/10.1128/MCB.01381-10; http://mcb.asm.org/cgi/doi/10.1128/MCB.01381-10; https://syndication.highwire.org/content/doi/10.1128/MCB.01381-10; https://dx.doi.org/10.1128/mcb.01381-10; https://mcb.asm.org/content/31/11/2287; https://mcb.asm.org/content/31/11/2287.abstract; https://mcb.asm.org/content/31/11/2287.full.pdf; http://mcb.asm.org/lookup/doi/10.1128/MCB.01381-10; https://mcb.asm.org/content/mcb/31/11/2287.full.pdf; https://journals.asm.org/doi/10.1128/MCB.01381-10; https://journals.asm.org/doi/abs/10.1128/MCB.01381-10; http://mcb.asm.org/content/31/11/2287; https://ohsu.pure.elsevier.com/en/publications/80b0d9f2-181c-478e-8381-2a7af074d85d; https://www.tandfonline.com/doi/abs/10.1128/MCB.01381-10
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