FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity
Molecular and Cellular Biology, ISSN: 0270-7306, Vol: 26, Issue: 9, Page: 3455-3467
2006
- 236Citations
- 222Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations236
- Citation Indexes235
- 235
- CrossRef208
- Policy Citations1
- Policy Citation1
- Captures222
- Readers222
- 222
Article Description
Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. In adipocyies and skeletal muscle, FATP1 translocates from an intracellular compartment to the plasma membrane in response to insulin. Here we show that insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in skeletal muscle of FATP1-knockout animals while basal LCFA uptake by both tissues was unaffected. Moreover, loss of FATP1 function altered regulation of postprandial serum LCFA, causing a redistribution of lipids from adipocyte tissue and muscle to the liver, and led to a complete protection from diet-induced obesity and insulin desensitization. This is the first in vivo evidence that insulin can regulate the uptake of LCFA by tissues via FATP1 activation and that FATPs determine the tissue distribution of dietary lipids. The strong protection against diet-induced obesity and insulin desensitization observed in FATP1-null animals suggests FATP1 as a novel antidiabetic target. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646239182&origin=inward; http://dx.doi.org/10.1128/mcb.26.9.3455-3467.2006; http://www.ncbi.nlm.nih.gov/pubmed/16611988; http://mcb.asm.org/cgi/doi/10.1128/MCB.26.9.3455-3467.2006; https://syndication.highwire.org/content/doi/10.1128/MCB.26.9.3455-3467.2006; https://www.tandfonline.com/doi/full/10.1128/MCB.26.9.3455-3467.2006; https://dx.doi.org/10.1128/mcb.26.9.3455-3467.2006; https://www.tandfonline.com/doi/abs/10.1128/MCB.26.9.3455-3467.2006; https://mcb.asm.org/content/26/9/3455; https://mcb.asm.org/content/26/9/3455.abstract; https://mcb.asm.org/content/26/9/3455.full.pdf; https://mcb.asm.org/content/mcb/26/9/3455.full.pdf; http://mcb.asm.org/content/26/9/3455; https://journals.asm.org/doi/10.1128/MCB.26.9.3455-3467.2006; https://journals.asm.org/doi/abs/10.1128/MCB.26.9.3455-3467.2006
American Society for Microbiology
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know