Investigation of the Relationship between Polymorphism of Human Leukocyte Antigen G (HLA-G) and Social Functioning of Patients with Schizophrenia
Russian Journal of Genetics, ISSN: 1608-3369, Vol: 58, Issue: 3, Page: 353-358
2022
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Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
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Article Description
Abstract: Disorders of social functioning are the most persistent consequences of schizophrenia and are an important factor influencing the prognosis of mental disorders. Considering the role of HLA-G in modulating the immunological relationship between the mother and the fetus and, as a consequence, its role in the development of the embryonic brain, we studied the influence of the INDEL polymorphism of the HLA-G gene on the social functioning of patients with schizophrenia. The study included 812 people with schizophrenia and schizophrenia spectrum disorders. It was found that, in carriers of the D/D genotype, there is a decrease in the level of social functioning in all areas, which increases the risk of an unfavorable functional outcome.
Bibliographic Details
Pleiades Publishing Ltd
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