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Polymorphism of the MAOA Gene (rs1137070) and Internet Addiction in Adolescents

Russian Journal of Genetics, ISSN: 1608-3369, Vol: 59, Issue: 10, Page: 1069-1075
2023
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  • 5
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  • 1
    Mentions
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  • Captures
    5
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

New Findings from Russian Academy of Sciences Update Understanding of Internet [Polymorphism of the maoa Gene (Rs1137070) and Internet Addiction In Adolescents]

2024 JAN 29 (NewsRx) -- By a News Reporter-Staff News Editor at Internet Daily News -- Investigators discuss new findings in Internet. According to news

Article Description

Abstract: Monoamine oxidase A (MAOA) catalyzes the degradation of norepinephrine, dopamine, and serotonin, i.e., neurotransmitters involved in the pathogenesis of pathological addictions, including internet addiction (IA). Gene MAOA has been actively studied in terms of genetic predisposition to the development of aggressive behavior potentially involved in the formation of IA. The study included 602 adolescents (9–18 years old, mean age = 14.6, SD = 1.7) from the Angara-Yenisei macroregion (Russians n = 329, Tuvans n = 158, Khakasses n = 72, other populations n = 43). The type of IA was assessed according to the Chen scale (Chen Internet Addiction Scale, CIAS); gene polymorphism was detected using real-time PCR. The distribution of the TT genotype of MAOA rs1137070 polymorphism associated with low activity of the monoamine oxidase A enzyme and aggressive behavior affected by IA was found to be significantly higher in Tuvan adolescents compared with Russian ones (31.1/21.2% p = 0.02). Pathological internet addiction (more than 65 points on the Chen scale) is often observed among Khakass adolescents compared to Russian ones (26.4/15.5%, p = 0.03). Thus, the allelic variant T of MAOA rs1137070 polymorphism appears to be a potential marker for dependent and aggressive behavior to form, Asian representatives being more susceptible to the development of pathological addictions than Russian adolescents.

Bibliographic Details

K. V. Kopylova; I. V. Marchenko; M. V. Shubina; N. N. Gorbacheva; I. A. Novitckii; M. V. Smolnikova

Pleiades Publishing Ltd

Biochemistry, Genetics and Molecular Biology

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