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Cytotoxic derivatives of (22R,23R)-dihydroxystigmastane

Russian Journal of Bioorganic Chemistry, ISSN: 1068-1620, Vol: 33, Issue: 3, Page: 326-333
2007
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(22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23- dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3β,5α,6β,22,23- pentahydroxystigmastane, (22R,23R)-5α,6α-oxido-3β,22,23- trihydroxystigmastane, (22R,23R)-5β,6β-oxido-3β,22,23- trihydroxystigmastane, and (22R,23R)-3β,6β,22,23-tetrahydroxystigmast- 4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line. © Nauka/Interperiodica 2007.

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