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Synthesis and evaluation of novel 6-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

Russian Journal of Bioorganic Chemistry, ISSN: 1068-1620, Vol: 40, Issue: 5, Page: 579-585
2014
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Article Description

A novel series of uracil derivatives with a 3,5-dimethylbenzyl group at the C-6 position were synthesized and evaluated as non-nucleoside HIV-1 reverse transcriptase inhibitors. Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. Some of the tested compounds showed moderate to potent activities against wildtype HIV-1, and N-1 alkylated derivatives were highly active.

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