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Regioselective Nitration of (2E)-3-Aryl-2-(4-arylthiazol-2-yl)acrylonitriles

Russian Journal of General Chemistry, ISSN: 1608-3350, Vol: 94, Issue: 10, Page: 2578-2585
2024
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Abstract: The reaction of (2E)-3-aryl-2-(4-aryl-1,3-thiazol-2-yl)acrylonitriles with an excess of nitric acid in AcOH proceeds regioselectively to afford previously unknown (2E)-3-aryl-2-(4-aryl-5-nitro-1,3-thiazol-2-yl)acrylonitriles in 82–96% yields.

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