Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
Annals of the Rheumatic Diseases, ISSN: 0003-4967, Vol: 67, Issue: 11, Page: 1505-1515
2008
- 241Citations
- 226Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations241
- Citation Indexes240
- 240
- CrossRef216
- Patent Family Citations1
- Patent Families1
- Captures226
- Readers226
- 226
Article Description
Animal models of rheumatoid arthritis (RA) are widely used for testing potential new therapies for RA. However, the question of which animal model is most predictive of therapeutic efficacy in human RA commonly arises in data evaluation. A retrospective review of the animal models used to evaluate approved, pending RA therapies, and compounds that were discontinued during phase II or III clinical trials found that the three most commonly used models were adjuvant-induced arthritis (AIA) in rats and collagen-induced arthritis (CIA) in rats and mice. Limited data were found for more recently developed genetically modified animal models. Examination of the efficacy of various compounds in these animal models revealed that a compound’s therapeutic efficacy, rather than prophylactic efficacy, in AIA and CIA models was more predictive of clinical efficacy in human RA than data from either model alone.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0003496724427131; http://dx.doi.org/10.1136/ard.2007.076430; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=54349089048&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18055474; https://linkinghub.elsevier.com/retrieve/pii/S0003496724427131; https://dx.doi.org/10.1136/ard.2007.076430; https://ard.bmj.com/content/67/11/1505
Elsevier BV
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