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Arthroscopic ankle arthrodesis in two alkaptonuria patients

BMJ Case Reports, ISSN: 1757-790X, Vol: 16, Issue: 10
2023
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  • 110
    Captures
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    Mentions
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Metric Options:   Counts1 Year3 Year

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  • Captures
    110
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Fukuoka University Reports Findings in Alkaptonuria (Arthroscopic ankle arthrodesis in two alkaptonuria patients)

2023 NOV 02 (NewsRx) -- By a News Reporter-Staff News Editor at Japan Daily Report -- New research on Nutritional and Metabolic Diseases and Conditions

Article Description

Alkaptonuria is a very rare disorder in which homogentisic acid accumulates due to a deficiency in the activity of homogentisic acid 1,2 dioxygenase. This deficiency results in deposition of a yellowish-brown pigment in connective tissue. Such deposition is termed € ochronosis' and leads to deterioration in the formation and structure of proteoglycans in hyaline cartilage. These actions lead to fragmentation and rapid destructive arthritis. Often, ochronotic arthritis appears at 40-60 years of age, and many patients are treated symptomatically. Here, we report two patients (three ankles) with ochronotic arthritis who were treated with ankle arthrodesis. In all cases, the postoperative clinical score improved, but the time needed for fusion was prolonged and symptomatic subtalar arthropathy developed in the early postoperative period.

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