Nuclear binding of tritiated actinomycin in surface epithelial cells from normal stomach and atrophic gastritis
Gut, ISSN: 0017-5749, Vol: 19, Issue: 10, Page: 870-874
1978
- 2Citations
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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- Citations2
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Article Description
Tritiated actinomycin binding to DNA is closely linked to the degree of repression in chromatin. 3H-AM binding to DNA is the most pronounced in nuclei of cells committed into cycle. Inversely, in cells in the last steps of their differentiation or (and) in the resting state (non-dividing cells), 3H-AM binding for DNA is diminished down to a baseline since it is limited by the deoxynucleoproteins. Epithelial cells of stomach mucosa and duodenum demonstrate an increased cell uptake of tritiated actinomycin from the surface to the bottom of the pits. In severe gastritis and in intestinalysed metaplasia this was abolished: with a uniform enhancement of 3H-AM binding. These findings seem to indicate that these cells are derepressed.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0018131805&origin=inward; http://dx.doi.org/10.1136/gut.19.10.870; http://www.ncbi.nlm.nih.gov/pubmed/81792; https://gut.bmj.com/lookup/doi/10.1136/gut.19.10.870; https://dx.doi.org/10.1136/gut.19.10.870; https://gut.bmj.com/content/19/10/870
BMJ
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